PrognostiCheck ®

Overview
PrognostiCheck® is a proprietary noninvasive measurement that depicts prognosis by illustrating the plasma cell membrane and the exchange between the intra and extracellular matrices. We use impedance plethysmography, a well-established vascular diagnostic technique to measure the values of resistance (R) and Reactance (Xc) and calculate Phase Angle (Pa). Phase Angle is the arc tangent of Xc/R converted to degrees. Without regression analysis and across disease states and populations Phase Angle clearly illustrates;

  1. The presence and progression of disease
  2. Fluid Balance and Nutrition Status (without regression predictions)
  3. The effectiveness of a pharmacologic or non-pharmacologic treatment intervention
  4. Giving an opportunity to modify it to try and optimize a response
  5. Predicts the timing of non-acute death
  6. Facilitating the transition from curative-restorative to palliative-hospice care (Transitive Care TM)

Top How PrognostiCheck® Works

  1. Our body is made of materials that have varying degrees of conductivity based upon water and cells
  2. The circuit is safe because the signal that is used is at a frequency and strength (current and voltage) so as not to stimulate or disturb any tissues.
  3. The measurement can be repeated as often as necessary to illustrate and report the information sought.
  4. The measured impedance is vectored into two parts; Resistance (R) and Reactance (Xc)
  5. The Phase Angle is the relationship between R and Xc defined mathematically (arc tangent Xc/R expressed in degree.)
    • The average Phase Angle is from 5 deg to 9 deg - the higher the value better the health
    • < 4 deg denotes serious illness and an opportunity for aggressive intervention.
    • Continued diminution denotes worsening condition and if in the presence of aggressive intervention: non-response.
    • < 2 deg impending death (unrecoverable).

Top Why it's Important
Since the Phase Angle illustrates changes that occur prior to those evidenced by cell counts, physical signs, biochemical assays and imaging techniques its value clearly complements the disease management process, providing the physician with valuable information sooner.

Phase angle determined by PrognostiCheck® detects changes in tissue electrical properties and is a reliable and objective prognostic indicator in several chronic conditions - such as HIV prognosis, liver disease prognosis, cancer prognosis, chronic obstructive pulmonary disease prognosis, breast cancer prognosis, colorectal cancer prognosis, pancreatic cancer prognosis and lung cancer prognosis and in patients receiving dialysis.

Top Applications
Since Phase Angle values reflect what is happening at the cellular level they act as an "early warning system". These values can be used for

  • To improve treatment
  • To detect disease
  • End of life management
  • Valuable time to Act