PrognostiCheck®

Prognostic role of Phase Angle in Advanced Colorectal Cancer

Phase angle, determined by bioelectrical impedance analysis (BIA), detects changes in tissue electrical properties and has been found to be a prognostic indicator in several chronic conditions—such as HIV, liver cirrhosis, chronic obstructive pulmonary disease, and lung cancer—and in patients receiving dialysis.

Here is an abstract from the study that was conducted From Cancer Treatment Centers of America to investigate the prognostic role of phase angle in advanced colorectal cancer.

A case series of 52 patients were evaluated with histological confirmed stage IV colorectal cancer. BIA was conducted on all patients and phase angle was calculated. The Kaplan-Meier method was used to calculate survival. Cox proportional hazard models were constructed to evaluate the prognostic effect of phase angle independent of other clinical and nutritional variables.
Results: Patients with a phase angle 5.57 had a median survival of 8.6 mo (95% CI: 4.8, 12.4; n = 26), whereas those with a phase angle >5.57 had a median survival of 40.4 mo (95% CI: 21.9, 58.8; n = 26; P = 0.0001).

In Summary,it was concluded that Phase angle is a prognostic indicator in patients with advanced colorectal cancer.

The PrognostiCheck® device measures Phase Angle that detects changes in tissue electrical properties and is a reliable and objective prognostic indicator in several chronic conditions.

Tags: Advanced colorectal cancer, nutritional assessment, Phase Angle, prognostic significance, survival