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Phase Angle as a Prognostic Factor for Post-Operative Complications

January 21st, 2010 | 7 Comments | Posted in Phase Angle, Prognosis, PrognostiCheck®

Bioelectric Impedance Analysis (BIA), and its parameter, phase angle, have been described as a prognostic tool in several clinical situations, but they have never been studied in surgical population

Here is an abstract from the study conducted by M.Barbosa-Silva, A.Barros to assess the importance of nutritional variables and parameters from BIA as predictors of post-operative complications in a multi variable regression model.

The nutritional status of 225 adult patients scheduled to undergo gastrointestinal surgery was assessed by several methods, including bioelectric impedance analysis and subjective global assessment. Potential confounding factors were also studied. Patients were screened for post-operative complications until hospital discharge.

Weight loss greater than 10%, subjective global assessment, nutritional risk assessment, ECM/BCM ratio and phase angle (from BIA) were the prognostic factors significantly associated with post-operative complications in the crude analysis. After adjusting for sex, age, marital status, tumors and pre-operative infections, only phase angle remained as a prognostic factor (RR=4.3; CI95% 1.6–11.8 for phase angle <−0.8 sd), while the other nutritional variables lost their association with post-operative complications.

From the study it was concluded that Phase angle remains an important prognostic factor for postoperative complications, even after adjusting for other individual predictors and confounders.

PrognostiCheck® device measures Phase Angle and the values derived from Phase Angle are associated with improvement, disease progression and treatment efficacy and the timing of non-acute death.

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Phase Angle predicts survival in haemodialysis patients

January 7th, 2010 | 3 Comments | Posted in Phase Angle, Prognosis, PrognostiCheck(R)

Phase angle is clearly associated with prognosis and survival as a powerful independent variable.

The higher the value of phase angle generally the healthier the subject indicating the ratio of cells and water is balanced and that the ability of the plasma cell membrane to hold the electrical signal is good.

PrognostiCheck® device measures Phase Angle and the values derived from Phase Angle are associated with improvement, disease progression and treatment efficacy and the timing of non-acute death.

Here is an abstract from the study that was conducted by Chertow GM, to determine the relation between phase angle by bioelectrical impedance analysis (BIA) and survival in haemodialysis patients.

The study was conducted on Three thousand nine adult patients on thrice weekly hemodialysis. Patients with amputations above the transmetatarsal site were excluded from participation.

Mean phase angle was 4.8 ± 1.8 degrees. Patients with narrow (low) phase angle experienced an increased relative risk (RR) of death (<3 degrees; RR 4.3; 95% confidence interval [Cl], 2.9–6.2; and 3 to 4 degrees); RR 2.2; 95% Cl, 1.6–3.2; compared with the ≥6 degrees reference). There were no significant differences in risk among patients with phase angle 4 to 5 degrees (RR 1.2; 95% Cl, 0.8–1.8), 5 to 6 degress (RR 1.1; 95% Cl, 0.7–1.7), and ≥6 degrees, suggesting a nonlinear relation between phase angle and survival. The RRs for phase angle <4 degrees remained statistically significant after adjusting for age, gender, race, serum albumin and creatinine concentrations, and dialysis intensity (<3 degrees, RR 2.2; 95% Cl, 1.6–3.1, and 3 to 4 degrees, RR 1.3; 95% Cl, 1.0–1.7, compared with all patients ≥4 degrees).

From the study it was concluded that In patients on hemodialysis, BIA-derived phase angle <4 degrees was associated with an increased RR of death, even after adjustment for case mix and several nutritional indicators.

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