PrognostiCheck®

Phase Angle predicts survival in haemodialysis patients

Phase angle is clearly associated with prognosis and survival as a powerful independent variable.

The higher the value of phase angle generally the healthier the subject indicating the ratio of cells and water is balanced and that the ability of the plasma cell membrane to hold the electrical signal is good.

PrognostiCheck® device measures Phase Angle and the values derived from Phase Angle are associated with improvement, disease progression and treatment efficacy and the timing of non-acute death.

Here is an abstract from the study that was conducted by Chertow GM, to determine the relation between phase angle by bioelectrical impedance analysis (BIA) and survival in haemodialysis patients.

The study was conducted on Three thousand nine adult patients on thrice weekly hemodialysis. Patients with amputations above the transmetatarsal site were excluded from participation.

Mean phase angle was 4.8 ± 1.8 degrees. Patients with narrow (low) phase angle experienced an increased relative risk (RR) of death (<3 degrees; RR 4.3; 95% confidence interval [Cl], 2.9–6.2; and 3 to 4 degrees); RR 2.2; 95% Cl, 1.6–3.2; compared with the ≥6 degrees reference). There were no significant differences in risk among patients with phase angle 4 to 5 degrees (RR 1.2; 95% Cl, 0.8–1.8), 5 to 6 degress (RR 1.1; 95% Cl, 0.7–1.7), and ≥6 degrees, suggesting a nonlinear relation between phase angle and survival. The RRs for phase angle <4 degrees remained statistically significant after adjusting for age, gender, race, serum albumin and creatinine concentrations, and dialysis intensity (<3 degrees, RR 2.2; 95% Cl, 1.6–3.1, and 3 to 4 degrees, RR 1.3; 95% Cl, 1.0–1.7, compared with all patients ≥4 degrees).

From the study it was concluded that In patients on hemodialysis, BIA-derived phase angle <4 degrees was associated with an increased RR of death, even after adjustment for case mix and several nutritional indicators.

Tags: disease progression, Disease severity, effectiveness of treatment, phase angle values, survival in haemodialysis patients

Bioelectrical phase angle values in a clinical sample of ambulatory rehabilitation patients

Phase angle is derived from the resistance(R) and reactance(Xc) measurements obtained from bioelectric impedance analysis (BIA) and is considered indicative of cellular health and membrane integrity.

PrognostiCheck® is a noninvasive measurement that uses a well-established vascular diagnostic technique to measure the values of resistance (R) and Reactance (Xc) and calculate phase angle . Phase angle is clearly associated with prognosis and survival as a powerful independent variable.

Here is an Abstract from a study conducted by Simon M Gunn that measured phase angle values of rehabilitation patients and compared them to reference values, measures of functional ability and serum C-reactive protein (CRP) levels to explore their utility as a clinical tool to monitor disease progression and treatment efficacy.

The study was conducted on 215 ambulatory rehabilitation patients aged 20 – 94 years. All participants had been hospitalized for a stroke, orthopedic or other condition resulting in a functional limitation. PhA was derived from BIA analysis and functional ability characterized using the Functional Independence Measure (FIM), timed up and go (TUG) and maximal quadriceps strength (MQS). Serum levels of CRP were also collected.

Stroke patients had the highest PhA (5.3°) followed by elective orthopedic surgery (5.0°) with the other group (4.3°) significantly lower than both previous categories (p < 0.001). Ambulatory rehabilitation patients' PhA values were dependent on age and sex (p < 0.001), lower than published age matched healthy reference values (p ≤ 0.05) and similar to other hospitalized or sick groups, but also higher than values reported in critically ill patients. Patients with CRP values less than 10 mg.L-1 had significantly (p = 0.005) higher mean PhA values. Furthermore, the highest functional status quartiles had significantly higher PhAs (p ≤ 0.04) for the FIM, MQS and TUG measures.

The results suggest that the phase angles of rehabilitation patients are between those of healthy individuals and seriously ill patients, thereby supporting claims that phase angle is indicative of general health status.

Phase angles are a potentially useful indicator of functional status in patients commencing an ambulatory rehabilitation program with a normal hydration status.

Tags: ambulatory rehabilitation patients, BIA Analysis, Phase Angle

Adenocarcinoma Prognosis

Adenocarcinoma is a carcinoma that begins in cells lining glandular types of internal organs (glandular epithelium tissue ) such as the lungs, breasts, colon, prostate, stomach, pancreas, and cervix and has gland-like properties.

PrognostiCheck® measures the prognosis of patients with Adenocarcinoma.

Check out the Slideshare Presentation on Adenocarcinoma Prognosis

Tags: adenocarcinoma, adenocarcinoma lung, Adenocarcinoma Prognosis, Cancer Prognosis, cancer treatment, Prognosis, treatment of cancer

Prognostic role of Phase Angle in Advanced Colorectal Cancer

Phase angle, determined by bioelectrical impedance analysis (BIA), detects changes in tissue electrical properties and has been found to be a prognostic indicator in several chronic conditions—such as HIV, liver cirrhosis, chronic obstructive pulmonary disease, and lung cancer—and in patients receiving dialysis.

Here is an abstract from the study that was conducted From Cancer Treatment Centers of America to investigate the prognostic role of phase angle in advanced colorectal cancer.

A case series of 52 patients were evaluated with histological confirmed stage IV colorectal cancer. BIA was conducted on all patients and phase angle was calculated. The Kaplan-Meier method was used to calculate survival. Cox proportional hazard models were constructed to evaluate the prognostic effect of phase angle independent of other clinical and nutritional variables.
Results: Patients with a phase angle 5.57 had a median survival of 8.6 mo (95% CI: 4.8, 12.4; n = 26), whereas those with a phase angle >5.57 had a median survival of 40.4 mo (95% CI: 21.9, 58.8; n = 26; P = 0.0001).

In Summary,it was concluded that Phase angle is a prognostic indicator in patients with advanced colorectal cancer.

The PrognostiCheck® device measures Phase Angle that detects changes in tissue electrical properties and is a reliable and objective prognostic indicator in several chronic conditions.

Tags: Advanced colorectal cancer, nutritional assessment, Phase Angle, prognostic significance, survival

Colon Cancer Prognosis

Colon cancer is cancer of the large intestine (colon), the lower part of your digestive system. Also called colon cancer or large bowel cancer,it includes cancerous growths in the colon, rectum and appendix.

A prognosis gives an idea of the likely course and outcome of a disease, the chance that a patient will recover or have a recurrence (return of the cancer).

PrognostiCheck® is a proprietary noninvasive measurement that depicts prognosis by illustrating the plasma cell membrane and the exchange between the intra and extracellular matrices.

Check out the slideshare

Tags: adenomatous polyps, Cancer Prognosis, colon cancer, colon cancer prognosis, colon cancer symptoms, colorectal cancer, intestine, Prognosis

Bioelectrical impedance Phase Angle as a Prognostic Indicator in advanced Pancreatic Cancer

Bioelectrical impedance analysis (BIA) is an easy-to-use, non-invasive and reproducible technique to evaluate changes in body composition and nutritional status. Phase angle, determined by BIA, has been validated for the assessment of body composition and nutritional status in a variety of patient populations including cancer patients.

The PrognostiCheck® device measures Phase Angle. Here is an abstarct from a study which investigated the prognostic role of phase angle in advanced pancreatic cancer.

The study investigated the prognostic role of phase angle in advanced pancreatic cancer. We evaluated a case series of fifty-eight stage IV pancreatic cancer patients treated at Cancer Treatment Centers of Americaw at Midwestern Regional Medical Center (Zion, IL, USA) between January 2000 and July 2003. BIA was conducted on all patients using a bioelectrical impedance analyser that operated at 50 kHz. The phase angle was calculated as capacitance (Xc)/resistance (R) and expressed in degrees. The Kaplan– Meier method was used to calculate survival. Cox proportional hazard models were constructed to evaluate the prognostic effect of phase angle independent of other clinical and nutritional variables. The correlations between phase angle and traditional nutritional measures were evaluated using Pearson and Spearman coefficients. Patients with phase angle ,5·08 had a median survival time of 6·3 (95 % CI 3·5, 9·2) months (n 29), while those with phase angle .5·08 had a median survival time of 10·2 (95 % CI 9·6, 10·8) months (n 29); this difference was statistically significant (P1⁄4 0·02)

In summary, this study has demonstrated the prognostic significance of the phase angle in advanced pancreatic cancer.

Tags: advanced pancreatic cancer, cancer treatment, Pancreatic cancer, Prognosis using PrognostiCheck®