Phase Angle predicts survival in haemodialysis patients
Phase angle is clearly associated with prognosis and survival as a powerful independent variable.
The higher the value of phase angle generally the healthier the subject indicating the ratio of cells and water is balanced and that the ability of the plasma cell membrane to hold the electrical signal is good.
PrognostiCheck® device measures Phase Angle and the values derived from Phase Angle are associated with improvement, disease progression and treatment efficacy and the timing of non-acute death.
Here is an abstract from the study that was conducted by Chertow GM, to determine the relation between phase angle by bioelectrical impedance analysis (BIA) and survival in haemodialysis patients.
The study was conducted on Three thousand nine adult patients on thrice weekly hemodialysis. Patients with amputations above the transmetatarsal site were excluded from participation.
Mean phase angle was 4.8 ± 1.8 degrees. Patients with narrow (low) phase angle experienced an increased relative risk (RR) of death (<3 degrees; RR 4.3; 95% confidence interval [Cl], 2.9–6.2; and 3 to 4 degrees); RR 2.2; 95% Cl, 1.6–3.2; compared with the ≥6 degrees reference). There were no significant differences in risk among patients with phase angle 4 to 5 degrees (RR 1.2; 95% Cl, 0.8–1.8), 5 to 6 degress (RR 1.1; 95% Cl, 0.7–1.7), and ≥6 degrees, suggesting a nonlinear relation between phase angle and survival. The RRs for phase angle <4 degrees remained statistically significant after adjusting for age, gender, race, serum albumin and creatinine concentrations, and dialysis intensity (<3 degrees, RR 2.2; 95% Cl, 1.6–3.1, and 3 to 4 degrees, RR 1.3; 95% Cl, 1.0–1.7, compared with all patients ≥4 degrees).
From the study it was concluded that In patients on hemodialysis, BIA-derived phase angle <4 degrees was associated with an increased RR of death, even after adjustment for case mix and several nutritional indicators.
January 7th, 2010 at 5:37 am
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