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Bioelectrical Impedance Phase Angle Changes During Hydration and Prognosis in Advanced Cancer

Here is an abstract from the study that was conducted to determine whether bioelectrical impedance (BIA) correlates before hydration or changes during hydration and determine if these changes were prognostically important.

Fifty eligible patients underwent BIA measurements 3 consecutive days. Laboratory studies (electrolytes, creatinine, and hemoglobin) on day 1; weights and vital signs were recorded. Kaplan-Meier survival estimates were made at 30 and 60 days. Hazard ratios (HRs) based on Cox proportional hazards model were calculated.

Results. Weight loss was associated with shorter survival. A higher phase angle (PA) on day 1 predicted longer survival. Increased PA during hydration predicted shorter survival: increased weight during hydration predicted longer survival.

Discussion. Higher phase angle before hydration predicts poorer survival and, paradoxically, an increase in phase angle during hydration predicted poorer survival and preexisting intracellular dehydration, cachexia, or poor membrane function.

Conclusions. Phase angle and weight during hydration predict survival in cancer.

PrognostiCheck® illustrates the timing of death to support end-of-life discussions,treatment options and the transition to palliative and hospice care.

Phase angle determined by PrognostiCheck® detects changes in tissue electrical properties and is a reliable and objective prognostic indicator in several chronic conditions.

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2 Responses to “Bioelectrical Impedance Phase Angle Changes During Hydration and Prognosis in Advanced Cancer”

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